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KMID : 0352519850220030139
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Korea Univercity Medical Journal
1985 Volume.22 No. 3 p.139 ~ p.144
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The Study on Clinical Diagnosis and Specific Serological Diagnosis of Hemorrhagic Fever with Renal Syndrome(HFRS)
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Abstract
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Epidemic hemorrhagic fever was recognized for the first time in Korea in 1951 among soldiers of the United Nations during Korean War. Since that time it has been known as Korean hemorrhagic fever (KHF).
In 1976 Lee and Lee successfully discovered an antigen in the lungs of Apodemus agrarius coreae which gave specific immunofluorescent reaction with convalescent sera from patients of KHF and in 1978, Lee et al. isolated this antigen from blood of KHF patients and perfected a specific serological test for diagnosis of KHF.
The aetiologic agent of KHF was identifical as a new member of Bunyaviridae and it was named Hantaan virus after the Hantaan river which runs near the 38th parallel between South and North Korea.
A close aetiological relationship was stablished between KHF and hemorrhagic fever with renal syndrome in USSR, nephropathia epidemics in Scandinavia and epidemic hemorrhagic fever in China and in Japan.
The working group on HFRS at a WHO meeting in Tokyo in Feb. 1982 recommended that the above mentioned diseases with different names should be referred to as "hemorrhagic fever with renal syndrome (HFRS)."
This report describes on difference between clinical diagnosis and specific serological diagnosis of HFRS. The indirect IF antibody technique was performed for serologic diagnosis of the patients having a symptom of HFRS from 1982 to 1984 and the results are summarized as follows.
1. Specific serological diagnosis to the 3571 cases of suspected HFRS clinically was shown that about 50% was proven to be of definite HFRS.
2. Blind sampling of 205 sera from the hospitalized patients was made to perform the i
specific serological diagnosis of HFRS, 4 cases was diagnosed HFRS serologically and of which 2 cases was diagnosed HFRS clinically but I case, chronic renal failure, and the other, G-1 bleeding.
3. Patients diagnosed G-I bleeding or acute abdomen in early stage of HFRS shall be subject to detailed specific serological diagnosis of HFRS since all of eight cases were expired after surgical operations.
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KEYWORD
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